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ea0049ep1118 | Female Reproduction | ECE2017

Influence of peroxisome proliferator-activated receptor (PPAR)-γ exon 2 (Pro12Ala) and exon 6 (His447His) and Gly972Arg insulin receptor substrate (IRS)-1 polymorphisms on insulin resistance (IR) and beta cell function in Southern Mediterranean women with polycystic ovary syndrome (PCOS)

Russo Giuseppina T , Pappalardo Maria Angela , Giandalia Annalisa , Romeo Elisabetta L , Alibrandi Angela , Bari Flavia Di , Vita Roberto , Cucinotta Domenico , Benvenga Salvatore

The Pro12Ala and His447His polymorphisms of PPAR-γ, and Gly972Arg polymorphism of IRS-1 have been implicated in insulin resistance (IR) and adiposity. In this study, we investigated the possible influence of these polymorphisms on metabolic features of 53 PCOS women compared with 26 healthy women (controls). All women underwent a clinical, anthropometric and biochemical evaluation, including a 75-g oral glucose tolerance test; insulin secretion and sensitivity indices wer...

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Endocrine Abstracts

Influence of peroxisome proliferator-activated receptor (PPAR)-γ exon 2 (Pro12Ala) and exon 6 (His447His) and Gly972Arg insulin receptor substrate (IRS)-1 polymorphisms on insulin resistance (IR) and beta cell function in Southern Mediterranean women with polycystic ovary syndrome (PCOS)

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